Growing Traffic With Report Advertising Through Report Directories ...

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Red Sox set season high in 15-run rout

By HOWARD ULMAN

AP Sports Writer

Associated Press Sports

updated 11:16 p.m. ET June 20, 2012

BOSTON (AP) - On the hottest day of the year in Boston, David Ortiz led the Red Sox to their biggest offensive attack of the season.

Ortiz continued his torrid hitting with a grand slam for one of their four homers as they set a season high in runs, beating the Miami Marlins 15-5 on Wednesday night.

The Red Sox pounded out 16 hits and won their fourth straight game and sixth in their last seven on a night when the game-time temperature was 95 degrees.

"The weather warmed up a little. Guys felt loose," Boston manager Bobby Valentine said.

Ortiz hit his 18th homer of the season, his third in three games and fourth in six, a span in which he is 9 for 20. The grand slam in a six-run fourth inning was the 11th of his career.

"I don't get many opportunities (with pitches) over the plate," he said. "I just try to be patient for that one pitch they give me to hit."

The Red Sox moved out of last place in the AL East at 35-33, passing Toronto after the Blue Jays lost 8-3 to Milwaukee.

Mike Aviles, Jarrod Saltalamacchia and Will Middlebrooks also homered one night after Ortiz hit one of Boston's three homers in a 7-5 victory over Miami.

"Hitting is definitely contagious and so is winning," Aviles said. "Any time you get a couple of wins together you just get that good confidence going and you just keep rolling with it and that's where we're at right now."

The Marlins lost for the 12th time in 14 games despite getting four runs and nine hits in six innings against Felix Doubront (8-3).

Ricky Nolasco (6-6) gave up nine runs and nine hits in 3 1-3 innings.

"I just think we're all trying to get on a positive run right now," he said. "It's just not happening. The last two games we swung the bats well. We just haven't pitched (well)."

The Red Sox offense has come alive in the past week with at least seven runs in four of their last six games.

On Wednesday, Aviles's three-run homer gave Boston a 3-2 lead in the second. In the third, Cody Ross' three-run double, on which Ortiz hustled home where the throw hit him and bounced away from catcher John Buck, made it 6-2.

"Guys are just getting on base left and right," Ross said. "We're coming up with big hits. Red Sox baseball."

Before the game, Miami manager Ozzie Guillen said he wouldn't change his lineup to help stop the slide. His offense has been better, scoring five runs in each game of the series after going 12 straight with four runs or less. But even when the Marlins scored, it wasn't always easy.

Buck hit his fifth homer, a solo shot that made it 13-5 in the seventh, but immediately clutched his right hamstring and trotted slowly around the bases. He remained in the game before leaving for a pinch hitter in the ninth.

For the second straight game, the Marlins led 2-0. They scored in the first on singles by Jose Reyes and Hanley Ramirez and a double-play grounder by Giancarlo Stanton. They added a run in the second on a double by Justin Ruggiano, a single by Omar Infante and a groundout by Gaby Sanchez.

But the Red Sox quickly jumped ahead by four runs after three innings.

"This is the type of game that can get you down and wonder what's going on," Guillen said. "The starting pitchers have not been doing their job of late."

The Marlins cut the lead to 6-4 in the fourth on a solo homer by Logan Morrison, who drove in all five runs on Tuesday, and a run-scoring groundout by Sanchez.

Boston drove Nolasco from the game in the fourth when singles by Aviles, Daniel Nava - who had four - and Ryan Kalish produced one run. After a single by Adrian Gonzalez loaded the bases, Ortiz hit his grand slam off Chris Hatcher. Saltalamacchia's 13th homer finished the inning.

Ortiz came up with the bases loaded again in the fifth, but Hatcher threw a wild pitch that allowed Nick Punto to score Boston's 13th run.

Middlebrooks hit his seventh homer, a two-run shot in the eighth.

NOTES: Boston 2B Dustin Pedroia missed the game as a precaution after feeling discomfort in his right hand on his last at bat in Tuesday night's win. ... Nolasco lost his third consecutive start and fourth in his last five. ... In Thursday night's series finale, Carlos Zambrano (4-5) is set to pitch for Miami against Daisuke Matsuzaka (0-2). ... The Red Sox signed SS Deven Marrero, their first-round pick and 24th overall in the amateur draft. He hit .325 in three seasons at Arizona State. He will be assigned to Single-A Lowell. ... Nava's four hits matched a career high set on June 1. ... Ortiz tied Joe Carter for 52nd place with 396 homers.

? 2012 The Associated Press. All rights reserved. This material may not be published, broadcast, rewritten or redistributed.

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Clemens not guilty, but shames game

??Costas: As the acquital of Roger Clemens proves, the public, and the juries who represent them, have decided that the crimes of steroid users are not against the law, but against the game.

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Stephen Strasburg struck out 10, Joel Peralta pitched without having his glove inspected, and Washington snapped a four-game losing streak Wednesday with a 3-2 win over Tampa Bay.

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Holder remains defiant: Contempt vote 'entirely unnecessary'

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Skiing News: Passive outdoor recreation grows, skiing, hunting ...

News on Skiing is found below:

Forest Service study takes big picture look at outdoor recreation trends By Summit Voice SUMMIT COUNTY ? Outdoor recreation in the U.S. is shifting toward more passive activities, with the biggest growth seen in areas like wildlife watching and photography, according to a new study published by the U.S. Forest Service Southern Research Station. Traditional

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Molecule thought cancer foe actually helps thyroid tumors grow

Wednesday, June 20, 2012

A molecule widely believed to fight many forms of cancer actually helps deadly thyroid tumors grow, and cancer therapies now being tested in humans might boost the activity of this newly revealed bad guy, researchers at Mayo Clinic in Florida say. Their findings are published online this month in the Journal of Cell Science.

The study found that in anaplastic thyroid cancer, the Forkhead transcription factor, FOXO3a, is not the helpful tumor suppressor everyone thought it was, but, instead, is a lethal promoter of tumor growth. When FOXO3a was silenced in laboratory models of human anaplastic thyroid cancer, the cells grew slowly, but when it was added, they grew much faster.

"This result is exactly the opposite of what we expected," says senior author John A. Copland, Ph.D., a Mayo cancer biologist. "We were more than surprised. We were concerned."

FOXO3a is known as a suppressor of tumor growth because it responds to all forms of cell stress, including that produced in cancer, by turning on genes inside the nucleus that trigger the cell's death. Cancer, in turn, is known to shut down FOXO3a by sending it out of the nucleus and into the cell's cytoplasm, where it is degraded. The molecule that ships FOXO3a out of the nucleus is Akt, which tries to keep cancer cells alive.

The research team used an Akt blocker ? similar to the ones now being used in human cancer clinical trials ? expecting to increase nuclear FOXO3a and suppress cancer growth in anaplastic thyroid cancer. They were trying to find a treatment for one of the deadliest known cancers, which accounts for just 2 percent of thyroid cancer cases in the U.S. but is responsible for about 40 percent of thyroid cancer deaths.

"The issue we are grappling with is that there are no effective treatments for this cancer. These tumors are so aggressive because there are so many genetic abnormalities," says study co-author Robert Smallridge, M.D., a Mayo endocrinologist who treats thyroid cancer patients. "We are studying what drives this cancer and how it can be treated."

The study showed that FOXO3a remained in the nucleus, with the use of an Akt inhibitor, and that instead of helping to kill cancer cells, FOXO3a was accelerating their growth. This raises concern about the use of Akt inhibitors since one of the mechanisms is to cause FOXO3a to remain active in the nucleus.

"We discovered a biological switch that turns FOXO3a from a good guy into a bad actor, but we don't know what that is yet, or in which cancers that might happen," says lead researcher Laura Marlow, a Mayo biologist.

"Cancer researchers, including those testing Akt inhibitors, should know that FOXO3a has pro-cancer activity as well as anti-cancer properties," Dr. Copland says. "Concern should be raised that an Akt inhibitor will enhance retention of FOXO3a in the nucleus, causing FOXO3a to remain active.

But there was some hopeful news regarding a potential therapy for the cancer. The researchers found that FOXO3a turns on a certain gene, cyclin A1, which promotes growth in the cancer cells. A different member of the cyclin family ? cyclin A2 ? is a well-known oncogene, but, before this study, no one had shown that cyclin A1 does the same thing as cyclin A2, says Peter Storz, Ph.D., a Mayo cancer biologist and co-author.

"It is not expressed much in human tissues and we found it highly expressed in anaplastic thyroid cancer," Dr. Smallridge says. "And that suggests that targeting cyclin A1 may be a possible strategy in treating anaplastic thyroid cancer."

###

Mayo Clinic: http://www.mayoclinic.org/news

Thanks to Mayo Clinic for this article.

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LiftingRevolution.com Relaunched By Top ... - Body Health & Fitness

Charleston, SC (PRWEB) June 14, 2012

Women these days are bashed, smashed, and crashed with diet, fitness, and health advice. But that?s the biggest problem, it?s just advice. And everyday on TV?s biggest shows and the industries biggest magazines, there is a new workout, new diet, new routine of living to experiment with. In a matter of just one week, a woman will have 5 different workouts to try, 5 different ways to eat, and 5 different ways to schedule her day how is that supposed to work?

Taylor says it doesn?t. That?s why women aren?t getting any significant results. But that?s all going to change.

Taylor Ryan is an NASM certified personal trainer and nutrition consultant. She?s been blogging on LiftingRevolution.com for a couple years, but was inspired to grow both the site and her audience to new levels. Taylor not only trains women in her home town of Charleston, SC but she also has an online training site. Needless to say she see and hears it all.

While shows like Dr. Oz and The Doctors provide really good information, it?s concentrated on really short tips and tricks. That is what creates attention and brings in an audience for advertisers. It?s the unfortunate reality of television shows.

But it?s these same tricks and tips that cause women more harm than good. ?I work with women that need to lose over 50 pounds fairly often.? says Taylor. ?They come in for a workout and realize how out of shape they are and it discourages them greatly. Many of them will not comeback for training saying they will just try Raspberry Keytones or some other fat burning like that. It?s really sad because it?s not going to work and these women will remain frustrated.?

So Taylor has invigorated her blog LiftingRevolution.com and her Facebook Page to help women understand the fat loss fundamentals. ?It?s working out. It?s nutrition. It?s community and having fun with women that share a passion for living healthy,? says Taylor. It?s one proven healthy living lifestyle. Not a mash of a million different fad workouts and diets. It?s focused and it works.

At one point in time, Taylor was 32 pounds overweight. She lost it all and even entered into a figure competition going all the way down to only 103 pounds. She?s been to both extremes. ?Women these days not only have a distorted outlook on being healthy because of these quick tips and tricks but they try to follow fitness models and their recommendations. These women don?t fully understand what goes into looking really good for a photo shoot and how unnatural everything is.?

Taylor hopes to continue the growth of LiftingRevolution.com and make it a premiere blog for real women to connect and learn how to live a real healthy lifestyle based on fundamentals that always produce results. Taylor says that living a healthy lifestyle is fun and energizing. It?s not tedious like women are lead to believe. So stop by her blog, say hello, and learn and be inspired by women burning fat everyday.

About LiftingRevolution and Taylor:

LiftingRevolution.com is a women?s fitness, nutrition, cooking, and motivational living blog. Taylor Ryan writes the posts on the blog daily. She runs it with her husband who helps her out in supporting roles. She is an expert trainer, nutrition consultant, and health writer. Contact Taylor today if you want to interview her, have her write for your publication or business, or proved workouts and nutrition plans.

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